童贻刚 简历 English Version

童贻刚

出生年月

1966-08

照片2011 (1)

研究室主任

专业技术

研究员

(何时、何校)

研究生(军事医学科学院)

(何时、何校)

博士(军事医学科学院)

工作单位

军事科学院军事医学研究院

通讯地址

北京市丰台区东大街20号

100071

单位电话

010-66948446

手机电话

136****2813

E-mail

tong.yigang@gmail.com

010-63869835

本人简历

1984.9-1988.6,复旦大学,遗传专业,学士

1988.9-1991.6,军事医学科学院,医学遗传学专业,硕士研究生

1991.7-1997.8,北京军区总医院,主治医师

1997.9-2000.6,军事医学科学院,微生物学专业,博士研究生

2000.7-2003.3,军事医学科学院微生物流行病研究所,副研究员,研究室副主任

2003.4-2005.4,加拿大不列颠哥伦比亚大学,博士后(期间获得Micheal Smith奖)

2005.5-至今,军事医学科学院微生物流行病研究所,研究员,研究室主任

国际病毒分类委员会(ICTV )细菌与古菌分会委员

中国援非抗埃医疗队首席科学家

中国微生物学会医学微生物学与免疫学专业委员会常务委员(噬菌体学组组长)

Genomics, Proteomics & Bioinformatics杂志编委

Virologica Sinica杂志编委

Journal of Bioterrorism and Biodefence杂志编委

临床肝胆病杂志编委

病毒学报编委

生物技术通讯编委

近五年 来承担的科研项目和课题

主持重点项目

1. 中国人民解放军后勤科研重大项目,项目编号:XXXXXXXX,项目名称:XXXXXXXX(秘密),实施时间:2016.1-2019.12,经费:3490万元。

2. “艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项“十二五”实施计划,项目编号:2013ZX10004605,项目名称:基于二代测序技术和生物信息学的病原微生物综合分析平台,实施时间:2013.01-2015.12,经费:830万元

主持课题:

3. 国家自然科学基金面上课题,课题编号:81672001,课题名称:埃博拉病毒基因组连续T-C突变的形成机制及其对病毒适应性的影响,实施时间:2017.1-2020.12,课题经费:57万元。

4. 国家“生物安全关键技术研发”重点专项,项目编号:2016YFC1202705,项目名称:XXXXXXXX(秘密),实施时间:2016.1-2018.12,课题经费:150万元。

5. 国家高技术研究发展计划(863计划) (课题名称:生物威胁病原体检测鉴定与溯源关键技术研究。项目编号:2012AA022-003。实施年限为2012. 1 -2015.12。课题经费:275万元。

6. “重大新药创制”科技重大专项“十二五”实施计划,项目编号:2011ZX09401-023。项目名称:企业创新药物孵化基地建设。课题名称:创新型抗体药物研究与核心技术体系建设。课题经费:100万元。实施时间:2011.01-2013.12。课题经费:100万元。

主要学术成就

童贻刚,军事医学科学院微生物流行病研究所研究员、教授、博士生导师,复旦大学遗传专业理学学士,军事医学科学院理学博士,加拿大不列颠哥伦比亚大学(UBC)博士后。长期从事微生物组学、病原体高通量测序、细菌耐药基因传播机制及噬菌体研究。 在微生物高通量测序和噬菌体研究方面处在国内的领先地位。 先后在Nature、PNAS、Lancet ID、Journal of Virology、 Journal of Biological Chemistry等刊物发表中英文论文200余篇,其中SCI论文130余篇。承担多项国家级研究课题,包括国家863课题、国家自然基金课题、国家传染病科技重大专项课题、国家重大新药创制科技重大专项课题、国家“生物安全关键技术研发”重点专项课题等,为国家传染病重大专项项目首席专家。建立了一种新的基因克隆技术——“基因组DNA剪接”技术,可以不通过mRNA直接从基因组DNA中克隆任何多外显子基因的全长cDNA序列;建立了一种简便的基因定点突变技术(DREAM突变技术);创建了利用高通量测序确定病毒基因组末端和发现溶原性噬菌体的方法。担任国际病毒分类委员会(ICTV )委员。曾作为中国第三批医疗队首席科学家 赴塞拉利昂参与埃博拉疫情防控。以第一作者身份在nature杂志发表的埃博拉病毒进化规律研究论文被评为2015年度中国科学十大进展之一。完成中国输入性寨卡病毒首例全基因组序列测定,并通过高通量测序发现我国首例输入性裂谷热病例。有关寨卡病毒和裂谷热病毒的研究工作分别发表于柳叶刀传染病杂志。2017年对广东省大面积仔猪疫情进行分析,发现一种新的冠状病毒,通过溯源与进化分析,证明其来源于广东地区的篇幅。该研究已投Nature,已经过二审,在等待最终裁决。

全部发表论文列表(实时更新)

SCI 论文(点击查看)

中文论文(点击查看)


近五年 来教学、科研成果(著作、论文、获奖等)

第一(共同第一)作者SCI 论文

1. Tong YG, Shi WF, Liu D, Qian J, Liang L, Bo XC, Liu J, Ren HG, Fan H, Ni M, Sun Y, Jin Y, Teng Y, Li Z, Kargbo D, Dafae F, Kanu A, Chen CC, Lan ZH, Jiang H, Luo Y, Lu HJ, Zhang XG, Yang F, Hu Y, Cao YX, Deng YQ, Su HX, Sun Y, Liu WS, Wang Z, Wang CY, Bu ZY, Guo ZD, Zhang LB, Nie WM, Bai CQ, Sun CH, An XP, Xu PS, Zhang XL, Huang Y, Mi ZQ, Yu D, Yao HW, Feng Y, Xia ZP, Zheng XX, Yang ST, Lu B, Jiang JF, Kargbo B, He FC, Gao GF, Cao WC. Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone. Nature. 2015 Aug 6;524(7563):93-6. Epub 2015 May 13.

2. Tong Y. Metagenome-wide Association Studies Potentiate Precision Medicine for Rheumatoid Arthritis. Genomics Proteomics Bioinformatics. 2015 Aug;13(4):208-9. Epub 2015 Oct 15. No abstract available.

通讯(共同通讯)作者SCI 论文

3. Zhao Y, Wang L, Zhang Z, Feng J, Kang H, Fang L, Jiang X, Zhang D, Zhan Z, Zhou D, Tong Y. Structural genomics of pNDM-BTR harboring In191 and Tn6360, and other bla (NDM)-carrying IncN1 plasmids. Future Microbiol. 2017 Oct 13. (SCI IF= 3.374)

4. Xing S, Zhang X, Sun Q, Wang J, Mi Z, Pei G, Huang Y, An X, Fu K, Zhou L, Zhao B, Tong Y. Complete genome sequence of a novel, virulent Ahjdlikevirus bacteriophage that infects Enterococcus faecium. Arch Virol. 2017 Dec;162(12):3843-3847. Epub 2017 Aug 16. (SCI IF= 2.058)

5. Teng Y, Liu S, Guo X, Liu S, Jin Y, He T, Bi D, Zhang P, Lin B, An X, Feng D, Mi Z, Tong Y. An Integrative Analysis Reveals a Central Role of P53 Activation via MDM2 in Zika Virus Infection Induced Cell Death. Front Cell Infect Microbiol. 2017 Jul 20;7:327. eCollection 2017. (SCI IF= 4.3)

6. Jiang T, Jiang JF, Deng YQ, Jiang BG, Fan H, Han JF, Hu Y, Zhuang DM, Kargbo D, An XP, Mi ZQ, Zhao GY, Xin WW, Tan YF, He J, Gao RB3, Wang H3, Chen C3, Wang F3, Li CX, Zhao JJ, Cui YJ, Bei ZC, Zhang K, Shang XY4, Zhang WH, Pei GQ, Wang YF, Wang W, Shu P, Liu WL, Cheng S, Zhu SY, Kanu A5, Kargbo B, Gao B, Tong YG, Fang TY, Cao WC.. Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses. J Infect Dis. 2017 Apr 1;215(7):1107-1110. doi: 10.1093/infdis/jix061. (SCI IF= 2.532)

7. Zhang Q, Xing S, Sun Q, Pei G, Cheng S, Liu Y, An X, Zhang X, Qu Y, Tong Y. Characterization and complete genome sequence analysis of a novel virulent Siphoviridae phage against Staphylococcus aureus isolated from bovine mastitis in Xinjiang, China. Virus Genes. 2017 Jun;53(3):464-476. Epub 2017 Mar 15. (SCI IF= 1.431)

8. Xing S, Ma T, Zhang X, Huang Y, Mi Z, Sun Q, An X, Fan H, Wu S, Wei L, Tong Y. First complete genome sequence of a virulent bacteriophage infecting the opportunistic pathogen Serratia rubidaea. Arch Virol. 2017 Jul;162(7):2021-2028. Epub 2017 Mar 6. (SCI IF= 2.058)

9. Teng Y, Bi D, Xie G, Jin Y, Huang Y, Lin B, An X, Tong Y, Feng D. Model-informed risk assessment for Zika virus outbreaks in the Asia-Pacific regions. J Infect. 2017 May;74(5):484-491. Epub 2017 Feb 9. (SCI IF= 4.201)

10. Zhang X, Guo X, Fan H, Zhao Q, Zuo S, Sun Q, Pei G, Cheng S, An X, Wang Y, Mi Z, Huang Y, Zhang Z, Tong Y, Zhou H, Zhang J. Complete genome sequence of Menghai flavivirus, a novel insect-specific flavivirus from China. Arch Virol. 2017 May;162(5):1435-1439. Epub 2017 Feb 7. (SCI IF= 2.058)

11. Teng Y, Bi D, Xie G, Jin Y, Huang Y, Lin B, An X, Feng D, Tong Y. Dynamic Forecasting of Zika Epidemics Using Google Trends. PLoS One. 2017 Jan 6;12(1):e0165085. eCollection 2017. (SCI IF= 2.806)

12. Sun Q, Zhao Q, An X, Guo X, Zuo S, Zhang X, Pei G, Liu W, Cheng S, Wang Y, Shu P, Mi Z, Huang Y, Zhang Z, Tong Y, Zhou H, Zhang J. Complete genome sequence of Menghai rhabdovirus, a novel mosquito-borne rhabdovirus from China. Arch Virol. 2017 Apr;162(4):1103-1106. Epub 2016 Dec 20. (SCI IF= 2.058)

13. Qu Y, Huang Y, Liu D, Huang Y, Zhang Z, Mi Z, An X, Tong Y, Lu J. High-Throughput Analysis of the T Cell Receptor Beta Chain Repertoire in PBMCs from Chronic Hepatitis B Patients with HBeAg Seroconversion. Can J Infect Dis Med Microbiol. 2016;2016:8594107. Epub 2016 Oct 13. (SCI IF= 1.459)

14. Butt AM, Nasrullah I, Qamar R, Tong Y. Evolution of codon usage in Zika virus genomes is host and vector specific. Emerg Microbes Infect. 2016 Oct 12;5(10):e107. doi: 10.1038/emi.2016.106. (SCI IF= 5.605)

15. Fan J, Zeng Z, Mai K, Yang Y, Feng J, Bai Y, Sun B, Xie Q, Tong Y, Ma J. Preliminary treatment of bovine mastitis caused by Staphylococcus aureus, with trx-SA1, recombinant endolysin of S. aureus bacteriophage IME-SA1. Vet Microbiol. 2016 Aug 15;191:65-71. Epub 2016 Jun 6. (SCI IF= 2.628)

16. Fan H, Zhao Q, Guo X, Sun Q, Zuo S, Wu C, Zhou H, An X, Pei G, Tong Y, Zhang J, Shi T. Complete genome sequence of Xishuangbanna flavivirus, a novel mosquito-specific flavivirus from China. Arch Virol. 2016 Jun;161(6):1723-7. Epub 2016 Mar 21. (SCI IF= 2.058)

17. Wang Y, Mi Z, Niu W, An X, Yuan X, Liu H, Li P, Liu Y, Feng Y, Huang Y, Zhang X, Zhang Z, Fan H, Peng F, Tong Y, Bai C. Intranasal treatment with bacteriophage rescues mice from Acinetobacter baumannii-mediated pneumonia. Future Microbiol. 2016 May;11:631-41. Epub 2016 Feb 29. (SCI IF= 0.958)

18. Butt AM, Raja AJ, Siddique S, Khan JS, Shahid M, Tayyab GU, Minhas Z, Umar M, Idrees M, Tong Y. Parallel expression profiling of hepatic and serum microRNA-122 associated with clinical features and treatment responses in chronic hepatitis C patients. Sci Rep. 2016 Feb 22;6:21510. doi: 10.1038/srep21510. (SCI IF= 4.259)

19. Pan Y, Liu R, Terpstra E, Wang Y, Qiao F, Wang J, Tong Y, Pan B. Dysregulation and diagnostic potential of microRNA in Alzheimer's disease. J Alzheimers Dis. 2016;49(1):1-12. Review. (SCI IF= 3.731)

20. Nasrullah I, Butt AM, Tahir S, Idrees M, Tong Y. Genomic analysis of codon usage shows influence of mutation pressure, natural selection, and host features on Marburg virus evolution. BMC Evol Biol. 2015 Aug 26;15:174. doi: 10.1186/s12862-015-0456-4. (SCI IF= 3.221)

21. Huang DD, Wang W, Lu QB, Zhao J, Guo CT, Wang HY, Zhang XA, Tong YG, Liu W, Cao WC. Identification of Bufavirus-1 and Bufavirus-3 in Feces of Patients with Acute Diarrhea, China. Sci Rep. 2015 Aug 19;5:13272. doi: 10.1038/srep13272. (SCI IF= 4.259)

22. Zhang X, Wang Y, Li S, An X, Pei G, Huang Y, Fan H, Mi Z, Zhang Z, Wang W, Chen Y, Tong Y. A novel termini analysis theory using HTS data alone for the identification of Enterococcus phage EF4-like genome termini. BMC Genomics. 2015 May 28;16:414. doi: 10.1186/s12864-015-1612-3. (SCI IF= 3.729)

23. Teng Y, Wang Y, Zhang X, Liu W, Fan H, Yao H, Lin B, Zhu P, Yuan W, Tong Y, Cao W. Systematic Genome-wide Screening and Prediction of microRNAs in EBOV During the 2014 Ebolavirus Outbreak. Sci Rep. 2015 May 26;5:9912. doi: 10.1038/srep09912. (SCI IF= 4.259)

24. Kang H, Xu X, Fu K, An X, Mi Z, Yin X, Peng F, Pei G, Wang Y, Huang Y, Zhang X, Zhang Z, Wang W, Zhou L, Chen J, Tong Y. Characterization and Genomic Analysis of Quinolone-Resistant Delftia sp. 670 Isolated from a Patient Who Died from Severe Pneumonia. Curr Microbiol. 2015 Jul;71(1):54-61. Epub 2015 May 3. (SCI IF= 1.322)

25. Ma MJ, Yang Y, Wang HB, Zhu YF, Fang LQ, An XP, Wan KL, Whalen CC, Yang XX, Lauzardo M, Zhang ZY, Cao JF, Tong YG, Dai EH, Cao WC. Transmissibility of tuberculosis among school contacts: an outbreak investigation in a boarding middle school, China. Infect Genet Evol. 2015 Jun;32:148-55. Epub 2015 Mar 7. (SCI IF= 2.885)

26. Pan Y, Sun L, Wang J, Fu W, Fu Y, Wang J, Tong Y, Pan B. STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis. Neuropharmacology. 2015 Jun;93:191-8. Epub 2015 Feb 12. (SCI IF= 5.012)

27. Huang Y, Li S, Zhao Q, Pei G, An X, Guo X, Zhou H, Zhang Z, Zhang J, Tong Y. Isolation and characterization of a novel invertebrate iridovirus from adult Anopheles minimus (AMIV) in China. J Invertebr Pathol. 2015 May;127:1-5. Epub 2015 Jan 28. (SCI IF= 2.379)

28. Liu W, Fan H, Raghwani J, Lam TT, Li J, Pybus OG, Yao HW, Wo Y, Liu K, An XP, Pei GQ, Li H, Wang HY, Zhao JJ, Jiang T, Ma MJ, Xia X, Dong YD, Zhao TY, Jiang JF, Yang YH, Guan Y, Tong Y, Cao WC. Occurrence and reassortment of avian influenza A (H7N9) viruses derived from coinfected birds in China. J Virol. 2014 Nov;88(22):13344-51. Epub 2014 Sep 10. (SCI IF= 4.663)

29. Hua Y, An X, Pei G, Li S, Wang W, Xu X, Fan H, Huang Y, Zhang Z, Mi Z, Chen J, Li J, Zhang F, Tong Y. Characterization of the morphology and genome of an Escherichia coli podovirus. Arch Virol. 2014 Dec;159(12):3249-56. Epub 2014 Aug 28. (SCI IF= 2.058)

30. Chen C, Fan H, Huang Y, Peng F, Fan H, Yuan S, Tong Y. Recombinant lysostaphin protects mice from methicillin-resistant Staphylococcus aureus pneumonia. Biomed Res Int. 2014;2014:602185. Epub 2014 Jul 16. (SCI IF= 2.476)

31. Wang Y, Wang W, Lv Y, Zheng W, Mi Z, Pei G, An X, Xu X, Han C, Liu J, Zhou C, Tong Y. Characterization and complete genome sequence analysis of novel bacteriophage IME-EFm1 infecting Enterococcus faecium. J Gen Virol. 2014 Nov;95(Pt 11):2565-75. Epub 2014 Jul 30. (SCI IF= 2.838)

32. Li S, An X, Huang Y, Pei G, Cao D, Mi Z, Gu Z, Zhao X, Li J, Gu G, Tong Y. Source tracking of an anthrax outbreak in northeastern China using complete genome analysis and MLVA genotyping. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):89-100. Epub 2014 Jul 31. (SCI IF= 2.727)

33. Peng F, Mi Z, Huang Y, Yuan X, Niu W, Wang Y, Hua Y, Fan H, Bai C, Tong Y. Characterization, sequencing and comparative genomic analysis of vB_AbaM-IME-AB2, a novel lytic bacteriophage that infects multidrug-resistant Acinetobacter baumannii clinical isolates. BMC Microbiol. 2014 Jul 5;14:181. doi: 10.1186/1471-2180-14-181. (SCI IF= 2.644)

34. Li X, Ding P, Han C, Fan H, Wang Y, Mi Z, Feng F, Tong Y. Genome analysis of Enterococcus faecalis bacteriophage IME-EF3 harboring a putative metallo-beta-lactamase gene. Virus Genes. 2014 Aug;49(1):145-51. Epub 2014 May 13. (SCI IF= 1.431)

35. Li C, An X, Butt AM, Zhang B, Zhang Z, Wang X, Huang Y, Zhang W, Zhang B, Mi Z, Tong Y. Construction of a chimeric secretory IgA and its neutralization activity against avian influenza virus H5N1. J Immunol Res. 2014;2014:394127. Epub 2014 Feb 13. (SCI IF= 3.276)

36. Zhuang L, Zhang Z, An X, Fan H, Ma M, Anderson BD, Jiang J, Liu W, Cao W, Tong Y. An efficient strategy of screening for pathogens in wild-caught ticks and mosquitoes by reusing small RNA deep sequencing data. PLoS One. 2014 Mar 11;9(3):e90831. eCollection 2014. (SCI IF= 2.806)

37. Butt AM, Nasrullah I, Tong Y. Genome-wide analysis of codon usage and influencing factors in chikungunya viruses. PLoS One. 2014 Mar 4;9(3):e90905. eCollection 2014. (SCI IF= 2.806)

38. Li S, Fan H, An X, Fan H, Jiang H, Chen Y, Tong Y. Scrutinizing virus genome termini by high-throughput sequencing. PLoS One. 2014 Jan 20;9(1):e85806. eCollection 2014. (SCI IF= 2.806)

39. Zhang W, Mi Z, Yin X, Fan H, An X, Zhang Z, Chen J, Tong Y. Characterization of Enterococcus faecalis phage IME-EF1 and its endolysin. PLoS One. 2013 Nov 13;8(11):e80435. eCollection 2013. (SCI IF= 2.806)

40. Mi Z, Butt AM, An X, Jiang T, Liu W, Qin C, Cao WC, Tong Y. Genomic analysis of HAdV-B14 isolate from the outbreak of febrile respiratory infection in China. Genomics. 2013 Nov-Dec;102(5-6):448-55. Epub 2013 Sep 20. (SCI IF= 2.801)

41. Huang Y, Mi Z, Zhuang L, Ma M, An X, Liu W, Cao W, Tong Y. Presence of entomobirnaviruses in Chinese mosquitoes in the absence of Dengue virus co-infection. J Gen Virol. 2013 Mar;94(Pt 3):663-7. Epub 2012 Nov 21. (SCI IF= 2.838)

42. Fan H, Fan H, An X, Huang Y, Zhang Z, Mi Z, Tong Y. Complete genome sequence of IME11, a new N4-like bacteriophage. J Virol. 2012 Dec;86(24):13861. doi: 10.1128/JVI.02684-12. (SCI IF= 4.663)

43. Huang Y, Fan H, Pei G, Fan H, Zhang Z, An X, Mi Z, Shi T, Tong Y. Complete genome sequence of IME15, the first T7-like bacteriophage lytic to pan-antibiotic-resistant Stenotrophomonas maltophilia. J Virol. 2012 Dec;86(24):13839-40. doi: 10.1128/JVI.02661-12. (SCI IF= 4.663)

44. Fan H, Huang Y, Mi Z, Yin X, Wang L, Fan H, Zhang Z, An X, Chen J, Tong Y. Complete Genome Sequence of IME13, a Stenotrophomonas maltophilia bacteriophage with large burst size and unique plaque polymorphism. J Virol. 2012 Oct;86(20):11392-3. (SCI IF= 4.663)

45. Butt AM, Nasrullah I, Tahir S, Tong Y. Comparative genomics analysis of Mycobacterium ulcerans for the identification of putative essential genes and therapeutic candidates. PLoS One. 2012;7(8):e43080. Epub 2012 Aug 13. Erratum in: PLoS One. 2013;8(9). (SCI IF= 2.806)

46. Mi Z, Ma Y, Tong Y. Avian influenza virus H5N1 induces rapid interferon-beta production but shows more potent inhibition to retinoic acid-inducible gene I expression than H1N1 in vitro. Virol J. 2012 Aug 3;9:145. doi: 10.1186/1743-422X-9-145. (SCI IF= 2.139)

Make your own free website on Tripod.com